Risk of specific cardiovascular diseases in obsessive-compulsive disorder

Individuals with obsessive-compulsive disorder (OCD) may have an increased risk of cardiovascular disease (CVD), but evidence for specific types CVD is limited. This population-based, sibling-controlled cohort study investigated the in individuals OCD. Linking data from various Swedish population-based registers, we explored a range diagnosed OCD between 1973 and 2013 (n = 33,561), compared to matched (1:10) unaffected 335,610). Hazard ratios (HR) 95% confidence intervals (CI) were calculated using conditional Cox proportional hazards regression models, adjusting history somatic diseases. To control familial confounders, analyzed 23,263 clusters full siblings discordant psychiatric comorbidities systematically excluded assess impact these comorbidities. Over average follow-up time 27 years, was associated broad (adjusted HR [aHR] any 1.25 [95% interval [CI], 1.22–1.29]). These associations strongest subtypes venous thrombo-embolism (aHR 1.48 CI, 1.38–1.58]) heart failure 1.37 1.28–1.46]). When comparing OCD-exposed their non-exposed siblings, results largely similar. Exclusion several groups resulted comparable results, albeit attenuated. moderately CVD-related morbidity, independent diseases, The be ripe development evaluation lifestyle interventions help reduce morbidity